Role of Orphan Nuclear Receptor DAX-1/NR0B1 in Development, Physiology, and Disease | Zendy

Enzo Lalli | Zendy

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Role of Orphan Nuclear Receptor DAX-1/NR0B1 in Development, Physiology, and Disease

Author(s) -

Enzo Lalli

Publication year - 2014

Publication title -

advances in biology

Language(s) - English

Resource type - Journals

eISSN - 2356-6582

pISSN - 2314-7563

DOI - 10.1155/2014/582749

Subject(s) - nuclear receptor , orphan receptor , biology , disease , endocrine system , transcription factor , physiology , neuron derived orphan receptor 1 , bioinformatics , function (biology) , genetics , gene , medicine , endocrinology , hormone

DAX-1/NR0B1 is an unusual orphan receptor that has a pivotal role in the development and function of steroidogenic tissues and of the reproductive axis. Recent studies have also indicated that this transcription factor has an important function in stem cell biology and in several types of cancer. Here I critically review the most important findings on the role of DAX-1 in development, physiology, and disease of endocrine tissues since the cloning of its gene twenty years ago

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