Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML | Zendy

Çiğdem Aydın | Zendy; Zafer Çetin | Zendy; Ozan Salim | Zendy; Orhan Kemal Yücel | Zendy; Levent Ündar | Zendy; Sibel Berker Karaüzüm | Zendy

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Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML

Author(s) -

Çiğdem Aydın,

Zafer Çetin,

Ozan Salim,

Orhan Kemal Yücel,

Levent Ündar,

Sibel Berker Karaüzüm

Publication year - 2014

Publication title -

case reports in genetics

Language(s) - English

Resource type - Journals

eISSN - 2090-6544

pISSN - 2090-6552

DOI - 10.1155/2014/582016

Subject(s) - chromosomal translocation , trisomy , trisomy 8 , medicine , chronic myelogenous leukemia , supernumerary , leukemia , karyotype , biology , microbiology and biotechnology , chromosome , genetics , immunology , gene , dentistry

Chronic myelogenous leukemia (CML) is a clonal hematological disorder, which is characterized by the presence of the classical or variant Philadelphia translocations. During the progression to blastic phase of the disease secondary chromosomal abnormalities may emerge. Such secondary chromosomal abnormalities are nonrandom, the more frequent ones being trisomy 8 and 19, supernumerary i(17q), and extra Philadelphia chromosomes. Furthermore, a minor percentage of the patients may acquire different secondary chromosomal abnormalities including translocations between other chromosomes. We report here a patient with Ph+ CML presenting secondary chromosomal abnormalities including t(4;11)(q21;q23), t(3;3)(q29;q23) and t(11;18)(q10;q10) during the course of CML progression.

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