Carboxymethyl Cellulose Acetate Butyrate: A Review of the Preparations, Properties, and Applications | Zendy

Mohamed ElSakhawy | Zendy; Samir Kamel | Zendy; Ahmed Salama | Zendy; Hebat-Allah Sarhan | Zendy

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Carboxymethyl Cellulose Acetate Butyrate: A Review of the Preparations, Properties, and Applications

Author(s) -

Mohamed ElSakhawy,

Samir Kamel,

Ahmed Salama,

Hebat-Allah Sarhan

Publication year - 2014

Publication title -

journal of drug delivery

Language(s) - English

Resource type - Journals

eISSN - 2090-3014

pISSN - 2090-3022

DOI - 10.1155/2014/575969

Subject(s) - carboxymethyl cellulose , dissolution , glass transition , solvent , butyric acid , butyrate , polymer , amorphous solid , organic chemistry , chemistry , salt (chemistry) , acetic acid , coating , cellulose , cellulose acetate , chemical engineering , materials science , sodium , fermentation , engineering

Carboxymethyl cellulose acetate butyrate (CMCAB) has gained increasing importance in several fields, particularly in coating technologies and pharmaceutical research. CMCAB is synthesized by esterification of CMC sodium salt with acetic and butyric anhydrides. CMCAB mixed esters are relatively high molecular weight (MW) thermoplastic polymers with high glass transition temperatures (Tg). CMCAB ester is dispersible in water and soluble in a wide range of organic solvents, allowing varied opportunity to the solvent choice. It makes application of coatings more consistent and defect-free. Its ability to slow down the release rate of highly water-soluble compounds and to increase the dissolution of poorly soluble compounds makes CMCAB a unique and potentially valuable tool in pharmaceutical and amorphous solid dispersions (ASD) formulations.

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