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Recent pharmacokinetic studies have suggested that nonrenal clearance predominates the elimination of polymyxin B. We present 2 patients with preexisting end stage renal failure, who were given nonattenuated doses of polymyxin B for the treatment of extreme-drug resistant organism. No evidence of adverse events occurred and microbiological clearance was documented.

case reports in infectious diseases

Nonattenuated Polymyxin B Used for the Treatment of Extreme-Drug ResistantAcinetobacter baumannii-Related Infections in Patients with Preexisting End Stage Renal Failure