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Osteopontin (OPN) is involved in the regulation of vascular calcification processes. The aim of this study was to evaluate the relationship between fasting serum OPN concentration and carotid-femoral pulse wave velocity (cfPWV) in geriatric persons. Fasting blood samples were obtained from 93 geriatric persons. cfPWV were performed by SphygmoCor system. Serum OPN levels were measured using a commercially available enzyme-linked immunosorbent assay. Geriatric adults who had diabetes ( P  = 0.007) or dyslipidemia ( P  = 0.029) had higher cfPWV levels than those without diabetes or dyslipidemia. The univariable linear regression analysis showed that age ( P  = 0.002), waist circumference ( P  = 0.048), body mass index ( P  = 0.004), systolic blood pressure ( P  = 0.001), diastolic blood pressure ( P  = 0.036), pulse pressure ( P  = 0.017), creatinine ( P  = 0.002), and log-OPN level ( P  = 0.001) were positively correlated with cfPWV levels, while the high-density lipoprotein cholesterol (HDL-cholesterol) level ( P  = 0.007) and glomerular filtration rate ( P  = 0.001) were negatively correlated with cfPWV levels among the geriatric adults. Multivariable forward stepwise linear regression analysis of the significant variables also showed that log-OPN ( β  = 0.233,  R   2  = 0.123, regression coefficient: 1.868,  P  = 0.011) was still an independent predictor of cfPWV levels in geriatric persons.

Serum Osteopontin Level Correlates with Carotid-Femoral Pulse Wave Velocity in Geriatric Persons