An Historical Perspective on How Advances in Microscopic Imaging Contributed to Understanding theLeishmaniaSpp. andTrypanosoma cruziHost-Parasite Relationship | Zendy

Pilar Tavares Veras Florentino | Zendy; Fernando Real | Zendy; Alexis BonfimMelo | Zendy; Cristina Mary Orikaza | Zendy; Éden Ramalho Ferreira | Zendy; C. C. Pessoa | Zendy; B. R. Lima | Zendy; Gisela Rodrigues da Silva Sasso | Zendy; Renato A. Mortara | Zendy

Open Access

An Historical Perspective on How Advances in Microscopic Imaging Contributed to Understanding theLeishmaniaSpp. andTrypanosoma cruziHost-Parasite Relationship

Author(s) -

Pilar Tavares Veras Florentino,

Fernando Real,

Alexis BonfimMelo,

Cristina Mary Orikaza,

Éden Ramalho Ferreira,

C. C. Pessoa,

B. R. Lima,

Gisela Rodrigues da Silva Sasso,

Renato A. Mortara

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/565291

Subject(s) - trypanosoma cruzi , biology , intracellular parasite , leishmania , context (archaeology) , intracellular , host (biology) , kinetoplastida , perspective (graphical) , computational biology , evolutionary biology , parasite hosting , microbiology and biotechnology , ecology , computer science , artificial intelligence , paleontology , world wide web

The literature has identified complex aspects of intracellular host-parasite relationships, which require systematic, nonreductionist approaches and spatial/temporal information. Increasing and integrating temporal and spatial dimensions in host cell imaging have contributed to elucidating several conceptual gaps in the biology of intracellular parasites. To access and investigate complex and emergent dynamic events, it is mandatory to follow them in the context of living cells and organs, constructing scientific images with integrated high quality spatiotemporal data. This review discusses examples of how advances in microscopy have challenged established conceptual models of the intracellular life cycles of Leishmania spp. and Trypanosoma cruzi protozoan parasites.

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