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The present study was designed to identify the DPPH (2, 2-diphenyl-1-picrylhydrazyl) free-radical scavenging constituents from methanol extract of  L. nodiflora  using bioassay-guided fractionation. The ethyl acetate fraction (EAF) revealed a strong antioxidant activity, compared to other fractions through  in vitro  DPPH radical-scavenging assay. The repeated fractionation of active EAF by silica gel column chromatography yielded a compound with strong antioxidant potential. The isolated bioactive compound was determined as 2-(3, 4-dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one (5-hydroxy-3′, 4′, 7-trimethoxyflavone), by comparing spectral data (UV, IR,  1 H NMR,  13 C NMR, and MS) with literature reports. The isolated compound demonstrated an excellent antioxidant activity through all antioxidant assays and also significantly inhibited lipid peroxidation at a concentration of 50   μ  g/mL. The results obtained suggested that extracts from  L. nodiflora  or its derived phytocompound can be used potentially as a bioactive source of natural antioxidants by contributing beneficial health effects.

Bioassay-Guided Isolation and Antioxidant Evaluation of Flavonoid Compound from Aerial Parts ofLippia nodifloraL.