Simultaneous Spectrophotometric Method for Determination of Emtricitabine and Tenofovir Disoproxil Fumarate in Three-Component Tablet Formulation Containing Rilpivirine Hydrochloride | Zendy

Sajıtha Venkatesan | Zendy; N. Kannappan | Zendy

Open Access

Simultaneous Spectrophotometric Method for Determination of Emtricitabine and Tenofovir Disoproxil Fumarate in Three-Component Tablet Formulation Containing Rilpivirine Hydrochloride

Author(s) -

Sajıtha Venkatesan,

N. Kannappan

Publication year - 2014

Publication title -

international scholarly research notices

Language(s) - English

Resource type - Journals

ISSN - 2356-7872

DOI - 10.1155/2014/541727

Subject(s) - rilpivirine , emtricitabine , tenofovir , medicine , component (thermodynamics) , pharmacology , human immunodeficiency virus (hiv) , virology , antiretroviral therapy , viral load , physics , thermodynamics

Developing a single analytical method for estimation of individual drug from a multidrug composition is a very challenging task. A complexation, derivatization, extraction, evaporation, and sensitive-free direct UV spectrophotometric method is developed and validated for the simultaneous estimation of some antiviral drugs such as emtricitabine (EMT), tenofovir disoproxil fumarate (TDF), and rilpivirine HCl (RPV) in tablet dosage form by Vierordt's method. The solutions of standard and sample were prepared in methanol. The λ max⁡ for emtricitabine, tenofovir disoproxil fumarate, and rilpivirine hydrochloride were 240.8 nm, 257.6 nm, and 305.6 nm, respectively. Calibration curves are linear in the concentration ranges 4–12 μ g/ml for EMT, 6–18 μ g/ml for TDF, and 0.5–1.5 μ g/ml for RPV, respectively. Results of analysis of simultaneous equation method were analyzed and validated for various parameters according to ICH guidelines.

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