Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione | Zendy

Biswanath Chakraborty | Zendy; Suchandra Chakraborty | Zendy; Chandan Saha | Zendy

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Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione

Author(s) -

Biswanath Chakraborty,

Suchandra Chakraborty,

Chandan Saha

Publication year - 2014

Publication title -

international journal of microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 40

eISSN - 1687-9198

pISSN - 1687-918X

DOI - 10.1155/2014/540208

Subject(s) - staphylococcus aureus , bacillus subtilis , antibacterial activity , escherichia coli , carbazole , moiety , chemistry , minimum inhibitory concentration , bacteria , microbiology and biotechnology , quinone , stereochemistry , biology , antibiotics , organic chemistry , biochemistry , genetics , gene

The antibacterial activity of Murrayaquinone A ( 10 ), a naturally occurring carbazoloquinone alkaloid, and 6-methoxy-3,7-dimethyl-2,3-dihydro-1 H -carbazole-1,4(9 H )-dione ( 11 ), a synthetic carbazoloquinone, both obtained during the development of the synthesis of Carbazomycin G, having unique quinone moiety, was studied against Gram-positive ( Bacillus subtilis and Staphylococcus aureus ) and Gram-negative ( Escherichia coli and Pseudomonas sp.) bacteria. Compound 10 showed antibacterial activities against both of Escherichia coli and Staphylococcus aureus whereas compound 11 indicated the activity against Staphylococcus aureus only. Both compounds 10 and 11 exhibited minimum inhibitory concentration (MIC) of 50 μ g mL −1 against Staphylococcus aureus .

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