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The antibacterial activity of Murrayaquinone A ( 10 ), a naturally occurring carbazoloquinone alkaloid, and 6-methoxy-3,7-dimethyl-2,3-dihydro-1 H -carbazole-1,4(9 H )-dione ( 11 ), a synthetic carbazoloquinone, both obtained during the development of the synthesis of Carbazomycin G, having unique quinone moiety, was studied against Gram-positive ( Bacillus subtilis  and  Staphylococcus aureus ) and Gram-negative ( Escherichia coli  and  Pseudomonas  sp.) bacteria. Compound  10  showed antibacterial activities against both of  Escherichia coli  and  Staphylococcus aureus  whereas compound  11  indicated the activity against  Staphylococcus aureus  only. Both compounds  10  and  11  exhibited minimum inhibitory concentration (MIC) of 50   μ  g mL −1  against  Staphylococcus aureus .

Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione