Computational Analysis of mRNA Expression Profiles Identifies theITGFamily andPIK3R3as Crucial Genes for Regulating Triple Negative Breast Cancer Cell Migration | Zendy

Sukhontip Klahan | Zendy; Mei-Shin Wu | Zendy; Edward Hsi | Zendy; ChiCheng Huang | Zendy; MingFeng Hou | Zendy; WeiChiao Chang | Zendy

Open Access

Computational Analysis of mRNA Expression Profiles Identifies theITGFamily andPIK3R3as Crucial Genes for Regulating Triple Negative Breast Cancer Cell Migration

Author(s) -

Sukhontip Klahan,

Mei-Shin Wu,

Edward Hsi,

ChiCheng Huang,

MingFeng Hou,

WeiChiao Chang

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/536591

Subject(s) - triple negative breast cancer , breast cancer , biology , estrogen receptor , gene , cancer research , progesterone receptor , cancer , microarray , estrogen receptor alpha , microarray analysis techniques , gene expression , genetics

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (Her2/neu). TNBC has worse clinical outcomes than other breast cancer subtypes. However, the key molecules and mechanisms of TNBC migration remain unclear. In this study, we compared two normalized microarray datasets from GEO database between Asian (GSE33926) and non-Asian populations (GSE46581) to determine the molecules and common pathways in TNBC migration. We demonstrated that 16 genes in non-Asian samples and 9 genes in Asian samples are related to TNBC migration. In addition, our analytic results showed that 4 genes, PIK3R3, ITGB1, ITGAL , and ITGA6 , were involved in the regulation of actin cytoskeleton. Our results indicated potential genes that link to TNBC migration. This study may help identify novel therapeutic targets for drug development in cancer therapy.

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