TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition | Zendy

Yu Tian | Zendy; Ming Lü | Zendy; Weiming Yue | Zendy; Lin Li | Zendy; Shuhai Li | Zendy; Cun Gao | Zendy; Libo Si | Zendy; Lei Qi | Zendy; Wensi Hu | Zendy; Hui Tian | Zendy

Open Access

TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition

Author(s) -

Yu Tian,

Ming Lü,

Weiming Yue,

Lin Li,

Shuhai Li,

Cun Gao,

Libo Si,

Lei Qi,

Wensi Hu,

Hui Tian

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/530786

Subject(s) - epithelial–mesenchymal transition , gene knockdown , cancer research , mesenchymal stem cell , lung cancer , cadherin , medicine , lung , immunohistochemistry , snail , transition (genetics) , vimentin , oncology , pathology , biology , cancer , cell , metastasis , cell culture , gene , ecology , biochemistry , genetics

In this study, we found that increased BRF2 protein expression was prevalent in NSCLC. Overexpression of BRF2 correlated with abnormal expression of E-cadherin, N-cadherin, and snail. Additionally, expression of BRF2 was found to be an independent prognostic factor in NSCLC patients. Furthermore, we showed that targeted knockdown of BRF2 expression could inhibit the migratory and invasive abilities of NSCLC cells and induced loss of the epithelial-mesenchymal transition of NSCLC cells. These results suggested that BRF2 overexpression in tumor tissues is significantly associated with the poor prognosis of NSCLC patients through promoting epithelial-mesenchymal transition (EMT) program.

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