Synthesis, Characterization andIn VitroAnticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation | Zendy

Amit Anthwal | Zendy; Bandana Thakur | Zendy; Mahiraj Singh Rawat | Zendy; Diwan S. Rawat | Zendy; Amit K. Tyagi | Zendy; Bharat B. Aggarwal | Zendy

Open Access

Synthesis, Characterization andIn VitroAnticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation

Author(s) -

Amit Anthwal,

Bandana Thakur,

Mahiraj Singh Rawat,

Diwan S. Rawat,

Amit K. Tyagi,

Bharat B. Aggarwal

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/524161

Subject(s) - curcumin , cytotoxicity , in vitro , chemistry , tumor necrosis factor alpha , cell culture , myeloid leukemia , pharmacology , cancer cell , cancer research , cancer , biochemistry , biology , medicine , immunology , genetics

In a search of new compounds active against cancer, synthesis of a series of C-5 curcumin analogues was carried out. The new compounds demonstrated good cytotoxicity against chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these compounds were found to have better potential to inhibit TNF- α -induced NF- κ B activation in comparison to curcumin, which show their potential to act as anti-inflammatory agents. Some compounds were found to show higher cytotoxicity against cancer cell lines in comparison to curcumin used as standard.

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