BAG3 and HIF-1αCoexpression Detected by Immunohistochemistry Correlated with Prognosis in Hepatocellular Carcinoma after Liver Transplantation | Zendy

Heng Xiao | Zendy; Rongliang Tong | Zendy; Shaobing Cheng | Zendy; Zhen Lv | Zendy; Chaofeng Ding | Zendy; Chengli Du | Zendy; Haiyang Xie | Zendy; Lin Zhou | Zendy; Jian Wu | Zendy; Shusen Zheng | Zendy

Open Access

BAG3 and HIF-1αCoexpression Detected by Immunohistochemistry Correlated with Prognosis in Hepatocellular Carcinoma after Liver Transplantation

Author(s) -

Heng Xiao,

Rongliang Tong,

Shaobing Cheng,

Zhen Lv,

Chaofeng Ding,

Chengli Du,

Haiyang Xie,

Lin Zhou,

Jian Wu,

Shusen Zheng

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/516518

Subject(s) - immunohistochemistry , liver transplantation , hepatocellular carcinoma , transplantation , medicine , stage (stratigraphy) , pathology , biology , paleontology

Objective . The objective is to determine the effects of BAG3 and HIF-1 α expression on the prognosis of HCC patients after liver transplantation. Methods . Samples from 31 patients with HCC receiving liver transplantation were collected for this study. The immunohistochemistry was used to detect the expression of BAG3 and HIF-1 α of HCC samples. Results . According to the immunohistochemistry results, BAG3 and HIF-1 α staining were significantly associated with tumor TNM stage ( P = 0.004, P = 0.012). A significant association between high BAG3/HIF-1 α levels and a shorter overall survival was detected, so as the combined BAG3 and HIF-1 α analysis. Conclusion . The results suggested that the expression level of BAG3 and HIF-1 α is efficient prognostic parameters in patients with HCC after liver transplantation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research