An Association Study between Genetic Polymorphism in the Interleukin-6 Receptor Gene and Coronary Heart Disease | Zendy

Jiangqing Zhou | Zendy; Xiaoliang Chen | Zendy; Huadan Ye | Zendy; Ping Peng | Zendy; Yanna Ba | Zendy; Xi Yang | Zendy; Xiaoyan Huang | Zendy; Yae Lu | Zendy; Xin Jiang | Zendy; Jiangfang Lian | Zendy; Shiwei Duan | Zendy

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An Association Study between Genetic Polymorphism in the Interleukin-6 Receptor Gene and Coronary Heart Disease

Author(s) -

Jiangqing Zhou,

Xiaoliang Chen,

Huadan Ye,

Ping Peng,

Yanna Ba,

Xi Yang,

Xiaoyan Huang,

Yae Lu,

Xin Jiang,

Jiangfang Lian,

Shiwei Duan

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/504727

Subject(s) - odds ratio , genotype , allele , polymorphism (computer science) , genetic model , medicine , bioinformatics , biology , genetics , gene

The goal of our study is to test the association of IL6R rs7529229 polymorphism with CHD through a case-control study in Han Chinese population and a meta-analysis. Our result showed there is a lack of association between IL6R rs7529229 polymorphism and CHD on both genotype and allele levels in Han Chinese ( P > 0.05). However, a meta-analysis among 11678 cases and 12861 controls showed that rs7529229-C allele was significantly associated with a decreased risk of CHD, especially in Europeans ( P < 0.0001, odds ratio = 0.93, 95% confidential interval = 0.89–0.96). Since there is significant difference among different populations, further studies are warranted to test the contribution of rs7529229 to CHD in other ethnic populations.

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