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Aim . The aim of this study was to investigate the prevalence and risk factors of  H. pylori  infection in areas with high prevalence of gastric cancer in Jiangsu Province, China.  Methods . A prospective epidemiologic survey of  H. pylori  infection was accomplished in a natural population of 5417 individuals in Yangzhong city. Questionnaires and 13C-urea breath test for  H. pylori  infection were performed.  Results . Among 5417 subjects who completed questionnaires and 13C-urea breath test, 3435 (63.41%) were  H. pylori  positive. The prevalence reached a peak at the age of 30–39 years (90.82%). There was significant difference between sexes and women had a higher infection rate than men. The prevalence of  H. pylori  infection was also associated with eating kipper food and fried food. No association between  H. pylori  prevalence and smoking or drinking was found. Compared to healthy individuals, people with dyspeptic diseases (peptic ulcer, gastroenteritis) presented a high prevalence of  H. pylori  infection. Using multivariate logistic regression analysis, age and history of peptic ulcer and gastroenteritis were the independent predictors for  H. pylori  infection.  Conclusions . Yangzhong city had a high prevalence of  H. pylori  infection and was related to several risk factors. The underlying mechanisms are needed to be further investigated.

Risk Factors and Prevalence ofHelicobacter pyloriInfection in Persistent High Incidence Area of Gastric Carcinoma in Yangzhong City