Silver Binding Nucleolar Organizer Regions Dots in Oral Leukoplakia with Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An In Vivo Study | Zendy

Fahad M. Samadi | Zendy; Bastain Thattil Sebastian | Zendy; Anil Singh | Zendy; Shaleen Chandra | Zendy; Shadab Mohammad | Zendy; Arun S. Singh | Zendy; Thippeswamy Shamenahalli Halappa | Zendy; Firoza Samadi | Zendy

Open Access

Silver Binding Nucleolar Organizer Regions Dots in Oral Leukoplakia with Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An In Vivo Study

Author(s) -

Fahad M. Samadi,

Bastain Thattil Sebastian,

Anil Singh,

Shaleen Chandra,

Shadab Mohammad,

Arun S. Singh,

Thippeswamy Shamenahalli Halappa,

Firoza Samadi

Publication year - 2014

Publication title -

isrn dentistry

Language(s) - English

Resource type - Journals

eISSN - 2090-438X

pISSN - 2090-4371

DOI - 10.1155/2014/479187

Subject(s) - oral leukoplakia , leukoplakia , nucleolus organizer region , dysplasia , basal cell , pathology , epithelial dysplasia , in vivo , carcinoma , nucleolar organizer region , medicine , cell , oral mucosa , biology , nucleolus , cancer , nucleus , genetics , psychiatry , microbiology and biotechnology

Silver binding nucleolar organizer regions (AgNOR) in normal oral mucosa (NOM), oral leukoplakia with epithelial dysplasia (ED), and oral squamous cell carcinoma (OSCC) were studied. The mean AgNOR count per nucleus increased from NOM to ED to OSCC. Tissue showing ED in oral leukoplakia and OSCC cases showed higher counts, wider scatter, and smaller size of AgNOR dots in the nuclei. The study seems to suggest that time method has some potential in distinguishing between NOM and oral leukoplakia with ED and OSCC. Studies of larger numbers are needed to arrive at more substantial conclusions.

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