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We examined the effects of iron oxide nanoparticles (IONPs) on mitochondrial respiratory chain complexes activities and mitochondrial coupling in young (3 months) and middle-aged (18 months) rat liver, organ largely involved in body iron detoxification. Isolated liver mitochondria were extracted using differential centrifugations. Maximal oxidative capacities ( V   max , complexes I, III, and IV activities),  V   succ  (complexes II, III, and IV activities), and  V   tmpd , (complex IV activity), together with mitochondrial coupling ( V   max / V   0 ) were determined in controls conditions and after exposure to 250, 300, and 350   μ  g/ml Fe 3 O 4  in young and middle-aged rats. In young liver mitochondria, exposure to IONPs did not alter mitochondrial function. In contrast, IONPs dose-dependently impaired all complexes of the mitochondrial respiratory chain in middle-aged rat liver:  V   max  (from 30 ± 1.6 to 17.9 ± 1.5;  P  < 0.001),  V   succ  (from 33.9 ± 1.7 to 24.3 ± 1.0;  P  < 0.01),  V   tmpd  (from 43.0 ± 1.6 to 26.3 ± 2.2  µ mol O 2 /min/g protein;  P  < 0.001) using Fe 3 O 4  350  µ g/ml. Mitochondrial coupling also decreased. Interestingly, 350   μ  g/ml Fe 3 O 4  in the form of Fe 3+  solution did not impair liver mitochondrial function in middle-aged rats. Thus, IONPs showed a specific toxicity in middle-aged rats suggesting caution when using it in old age.

biomed research international

Age Modulates Fe<sub>3</sub>O<sub>4</sub>Nanoparticles Liver Toxicity: Dose-Dependent Decrease in Mitochondrial Respiratory Chain Complexes Activities and Coupling in Middle-Aged as Compared to Young Rats

Age Modulates Fe3O4Nanoparticles Liver Toxicity: Dose-Dependent Decrease in Mitochondrial Respiratory Chain Complexes Activities and Coupling in Middle-Aged as Compared to Young Rats

Age Modulates Fe₃O₄Nanoparticles Liver Toxicity: Dose-Dependent Decrease in Mitochondrial Respiratory Chain Complexes Activities and Coupling in Middle-Aged as Compared to Young Rats