Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm | Zendy

Gary M. Woods | Zendy; Rajinder Bajwa | Zendy; Samir B. Kahwash | Zendy; Terri Guinipero | Zendy

Open Access

Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm

Author(s) -

Gary M. Woods,

Rajinder Bajwa,

Samir B. Kahwash,

Terri Guinipero

Publication year - 2014

Publication title -

case reports in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.2

H-Index - 20

eISSN - 1687-9627

pISSN - 1687-9635

DOI - 10.1155/2014/473297

Subject(s) - myeloproliferative neoplasm , myeloid leukemia , medicine , myeloproliferative disorders , mutation , myeloid , lineage (genetic) , girl , leukemia , jak2 v617f , population , cancer research , oncology , myelofibrosis , genetics , gene , biology , bone marrow , environmental health

Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by hyperproliferation of hematologic cell lines and have been associated with tyrosine kinase JAK2-V617F mutations. Secondary acute myeloid leukemia (sAML) is a known complication of JAK2-V617F+ MPNs and bears a poor prognosis. Although the evolution of a JAK2-V617F+ MPN to a mixed-lineage leukemia has been reported in the pediatric population, no evolutions into sAML have been described. We present a case of a one-year-old girl diagnosed with JAK2-V617F+ MPN with evolution into sAML. Despite initial morphologic remission, she eventually relapsed and succumbed to her disease.

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