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The aim of this study was to establish a retrospective evaluation and comparison of the hydrogen/methane (H 2 /CH 4 ) breath test and genetic test (C/T −13910  polymorphism) results in lactose malabsorption testing. In total 263 consecutive patients with suspected lactose malabsorption were included in this study. They underwent the H 2 /CH 4  breath test following the ingestion of 50 g lactose and were tested for the C/T −13910  polymorphism. In total 51 patients (19.4%) had a C/C −13910  genotype, indicating primary lactose malabsorption. Only 19 patients (7.2%) also had a positive H 2 /CH 4  breath test. All in all 136 patients (51.69%) had a C/T −13910  and 76 patients (28.91%) a T/T −13910  genotype, indicating lactase persistence. Four patients (1.5%) with the C/T −13910  genotype and one patient (0.4%) with the T/T −13910  genotype had a positive H 2 /CH 4  breath test result, indicating secondary lactose malabsorption. Cohen's Kappa measuring agreement between the two methods was 0.44. Twenty patients (7.6%) with a positive H 2 /CH 4  peak within 60 minutes after lactose ingestion were classified as patients with lactose-dependent small intestinal bacterial overgrowth (SIBO). In conclusion, only moderate agreement between the breath test and the genetic test was shown. Secondary lactose malabsorption as well as preanalytical limitations of the combined H 2 /CH 4  breath test procedure can cause discrepant results. This trial is registered with K-42-13.

gastroenterology research and practice

Lactose Malabsorption Testing in Daily Clinical Practice: A Critical Retrospective Analysis and Comparison of the Hydrogen/Methane Breath Test and Genetic Test (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mtext>C</mml:mtext><mml:mo>/</mml:mo><mml:mtext>T</mml:mtext></mml:mrow><mml:mrow><mml:mo>-</mml:mo><mml:mtext>13910</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>Polymorphism) Results

Lactose Malabsorption Testing in Daily Clinical Practice: A Critical Retrospective Analysis and Comparison of the Hydrogen/Methane Breath Test and Genetic Test (C/T-13910Polymorphism) Results