Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers | Zendy

Jiaqiu Li | Zendy; Hongchuan Jin | Zendy; Xian Wang | Zendy

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Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers

Author(s) -

Jiaqiu Li,

Hongchuan Jin,

Xian Wang

Publication year - 2014

Publication title -

isrn gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 2090-4401

pISSN - 2090-4398

DOI - 10.1155/2014/464015

Subject(s) - epigenetics , dna methylation , histone , biology , cancer , cancer epigenetics , carcinogenesis , chromatin , chromatin remodeling , cancer research , computational biology , bioinformatics , medicine , genetics , dna , gene , gene expression , histone methyltransferase

Genetics and epigenetics coregulate the cancer initiation and progression. Epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, and noncoding RNAs. Aberrant epigenetic modifications play a fundamental role in the formation of gastrointestinal cancers. Advances in epigenetics offer a better understanding of the carcinogenesis and provide new insights into the discovery of biomarkers for diagnosis, and prognosis prediction of human cancers. This review aims to overview the epigenetic aberrance and the clinical applications as biomarkers in gastrointestinal cancers mainly gastric cancer and colorectal cancer.

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