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The present study reports the  in vitro  antioxidant, antibacterial, and cytotoxic potential of  Syngonium podophyllum  (SP) and  Eichhornia crassipes  (EC) leaf aqueous extracts as well as their  in vivo  effect on oxidative stress and hepatic biomarkers in isoniazid induced rats. Phytochemical screening of extracts revealed the presence of flavonoids, terpenoids, reducing sugars, alkaloids, and saponins. Phenolic content in SP and EC extracts was 5.36 ± 0.32 and 10.63 ± 0.13 mg PGE/g, respectively, while flavonoid content was 1.26 ± 0.03 and 0.51 ± 0.03  μ g QE/mg, respectively. EC extract exhibited comparatively better antioxidant activity as indicated by reducing power (0.197–0.775), DPPH radical scavenging potential (11%–96%), and metal ion chelating ability (42%–93%). Both the extracts provided 13%–65% protection against lipid peroxidation in rat tissue (liver, kidney, and brain) homogenate. SP and EC extracts exhibited 51% and 43% cytotoxicity against lung cancer (NCI-H322) cell line, respectively. Both extracts demonstrated considerable antibacterial activity against  Proteus vulgaris ,  Salmonella typhi , and  Bordetella bronchiseptica . Coadministration of  E. crassipes  extract with isoniazid in rats accounted for 46% decrease in malondialdehyde content and 21% increase in FRAP value of plasma. It also mitigated the isoniazid induced alterations in serum enzymes (SGOT, SGPT, and ALP), total bilirubin, creatinine, and hemoglobin contents.  S. podophyllum  extract was found to be hepatotoxic.

biomed research international

In VitroAntioxidant, Antibacterial, and Cytotoxic Activity andIn VivoEffect ofSyngonium podophyllumandEichhornia crassipesLeaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers