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LUFFACHITIN  obtained from the residue of the sponge-like dried fruit of  Luffa aegyptiaca  was developed as a weavable skin substitute in this study. A chemical analysis revealed that  LUFFACHITIN  was composed of a copolymer containing N-acetyl-glucosamine (~40%) as a major monomer with a filamentary structure as demonstrated by both optical and scanning electron microscopy. The pulp-like white residue of the sponge-like dried fruit of  Luffa aegyptiaca  after treatment was then woven into a thin, porous membrane by filtration and lyophilization as a skin substitute for conducting wound-healing study on rats. The results indicated that the  LUFFACHITIN  membrane showed significant wound-healing enhancement (25 days to complete healing) compared to cotton gauze (>30 days), but not inferior to that of  SACCHACHITIN . Furthermore, the  LUFFACHITIN  membrane had advantages of having a high yield, better physical properties for fabrication, and a more attractive appearance.

Dried Fruit of theLuffaSponge as a Source of Chitin for Applications as Skin Substitutes