Measurement and Correlation for Solubility of Some Pyrimidine Derivatives in Different Solvents | Zendy

Kapil Bhesaniya | Zendy; Shipra Baluja | Zendy

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Measurement and Correlation for Solubility of Some Pyrimidine Derivatives in Different Solvents

Author(s) -

Kapil Bhesaniya,

Shipra Baluja

Publication year - 2014

Publication title -

journal of applied chemistry

Language(s) - English

Resource type - Journals

eISSN - 2314-6923

pISSN - 2356-7171

DOI - 10.1155/2014/450294

Subject(s) - solubility , dissolution , enthalpy , chemistry , methanol , gibbs free energy , atmospheric pressure , pyrimidine metabolism , molar solubility , pyrimidine , carbon tetrachloride , thermodynamics , organic chemistry , stereochemistry , physics , oceanography , purine , enzyme , geology

Some new pyrimidine derivatives have been synthesized and their characterization was done by IR, NMR, and mass spectral data. The solubility of these synthesized compounds has been studied in methanol, N,N dimethylformamide (DMF), and carbon tetrachloride (CCl4) by gravimetrical method from 298.15 to 328.15 K under atmospheric pressure and the solubility data were correlated against temperature. The solubility is found to increase with temperature and order of solubility is DMF > methanol > CCl4. The experimental solubility data is correlated with the modified Apelblat equation. Some thermodynamic parameters such as dissolution enthalpy, Gibbs energy of dissolution, and entropy of mixing have also been calculated

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