Effect of Indoxyl Sulfate on Oxidative Stress, Apoptosis, and Monocyte Chemoattractant Protein-1 in Leukocytes | Zendy

Edgar Ferreira da Cruz | Zendy; Miguel Cendoroglo | Zendy; Sílvia Regina Manfredi | Zendy; Maria Eugênia Fernandes Canziani | Zendy; Beata Marie Redublo Quinto | Zendy; Caren Cristina Grabulosa | Zendy; Nadia Guimarães-Souza | Zendy; Aline Trevisan Peres | Zendy; José Tarcísio Giffoni de Carvalho | Zendy; Marcelo Costa Batista | Zendy; Maria Aparecida Dalboni | Zendy

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Effect of Indoxyl Sulfate on Oxidative Stress, Apoptosis, and Monocyte Chemoattractant Protein-1 in Leukocytes

Author(s) -

Edgar Ferreira da Cruz,

Miguel Cendoroglo,

Sílvia Regina Manfredi,

Maria Eugênia Fernandes Canziani,

Beata Marie Redublo Quinto,

Caren Cristina Grabulosa,

Nadia Guimarães-Souza,

Aline Trevisan Peres,

José Tarcísio Giffoni de Carvalho,

Marcelo Costa Batista,

Maria Aparecida Dalboni

Publication year - 2014

Publication title -

isrn oxidative medicine

Language(s) - English

Resource type - Journals

ISSN - 2314-6400

DOI - 10.1155/2014/412389

Subject(s) - monocyte , peripheral blood mononuclear cell , oxidative stress , apoptosis , chemotaxis , inflammation , toxin , immunology , medicine , chemistry , biochemistry , receptor , in vitro

This study showed that indoxyl sulfate, an uremic toxin present in the serum of patients with chronic kidney disease, increases oxidative stress and apoptosis in human neutrophils and reduces the production of monocyte chemoattractant protein-1 (MCP-1) by peripheral blood mononuclear cell (PBMC). It is possible that these effects caused by this toxin contribute to vascular injury of the endothelium and decreased response to infectious insults, respectively.

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