Synthesis of Novel Pyridopyridazin-3(2H)-one Derivatives and Evaluation of Their Cytotoxic Activity against MCF-7 Cells | Zendy

Periasamy Selvakumar | Zendy; Sathiah Thennarasu | Zendy; Asit Baran Mandal | Zendy

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Synthesis of Novel Pyridopyridazin-3(2H)-one Derivatives and Evaluation of Their Cytotoxic Activity against MCF-7 Cells

Author(s) -

Periasamy Selvakumar,

Sathiah Thennarasu,

Asit Baran Mandal

Publication year - 2014

Publication title -

isrn medicinal chemistry

Language(s) - English

Resource type - Journals

ISSN - 2314-629X

DOI - 10.1155/2014/410716

Subject(s) - mcf 7 , chemistry , phenylhydrazine , yield (engineering) , amide , intramolecular force , hydrazine (antidepressant) , cytotoxic t cell , medicinal chemistry , human breast , stereochemistry , in vitro , organic chemistry , biochemistry , biology , genetics , materials science , cancer , cancer cell , metallurgy

A series of pyridopyridazin-3(2H)-one derivatives was synthesized in two facile steps. Mannich-type three-component condensation afforded the 2,6-diaryl piperidin-4-one derivatives, which underwent intramolecular cyclization in the presence of hydrazine or phenylhydrazine to yield the corresponding pyridopyridazin-3(2H)-one derivatives. All the derivatives of pyridopyridazin-3(2H)-one, except 3e and 3f, showed moderate activity against human breast adenocarcinoma (MCF-7) cells. The higher degree of inhibition of MCF-7 cell proliferation shown by 2a–2f indicates the significance of the amide proton in pyridopyridazin-3(2H)-one derivatives.

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