Demonstration of Redox Potential ofMetschnikowia koreensisfor Stereoinversion of Secondary Alcohols/1,2-Diols | Zendy

Vachan Singh Meena | Zendy; Linga Banoth | Zendy; Uttam Chand Banerjee | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Demonstration of Redox Potential ofMetschnikowia koreensisfor Stereoinversion of Secondary Alcohols/1,2-Diols

Author(s) -

Vachan Singh Meena,

Linga Banoth,

Uttam Chand Banerjee

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/410530

Subject(s) - chemistry , stereoselectivity , cofactor , redox , yield (engineering) , enantiomeric excess , organic chemistry , aryl , stereochemistry , combinatorial chemistry , catalysis , enzyme , enantioselective synthesis , materials science , alkyl , metallurgy

The present work reports the Metschnikowia koreensis -catalyzed one-pot deracemization of secondary alcohols/1,2-diols and their derivatives with in vivo cofactor regeneration. Reaction is stereoselective and proceeds with sequential oxidation of ( R )-secondary alcohols to the corresponding ketones and the reduction of the ketones to ( S )-secondary alcohols. Method is applicable to a repertoire of racemic aryl secondary alcohols and 1,2-diols establishing a wide range of substrate specificity of M. koreensis . This ecofriendly method afforded the product in high yield (88%) and excellent optical purity (>98% ee ), minimizing the requirement of multistep reaction and expensive cofactor.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research