Polymorphisms ofβ1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis | Zendy

А. Yu. Babenko | Zendy; Elena Grineva | Zendy; D A Savitskaja | Zendy; Е. Н. Кравчук | Zendy; V. N. Solncev | Zendy; Anna Kostareva | Zendy

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Polymorphisms ofβ1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis

Author(s) -

А. Yu. Babenko,

Elena Grineva,

D A Savitskaja,

Е. Н. Кравчук,

V. N. Solncev,

Anna Kostareva

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/402897

Subject(s) - medicine , atrial fibrillation , cardiology , cardiac function curve , left ventricular hypertrophy , endocrinology , heart failure , blood pressure

Human cardiac β 1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine. Gly389Arg and Ser49Gly polymorphisms of β 1-adrenoreceptors ( β 1-AR) can influence the cardiovascular prognosis. However, the possible effect of Gly389Arg and Ser49Gly polymorphisms on heart function in thyrotoxicosis has not been studied. We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders. Echo-CG was performed according to standard protocol before and during the thyreostatic treatment. Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications.

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