Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides fromβ-Lactoglobulin Secreted byLactococcus lactis | Zendy

Suguru Shigemori | Zendy; Kazushi Oshiro | Zendy; Pengfei Wang | Zendy; Yoshinari Yamamoto | Zendy; Yeqin Wang | Zendy; Takashi Sato | Zendy; Yutaka Uyeno | Zendy; Takeshi Shimosato | Zendy

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Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides fromβ-Lactoglobulin Secreted byLactococcus lactis

Author(s) -

Suguru Shigemori,

Kazushi Oshiro,

Pengfei Wang,

Yoshinari Yamamoto,

Yeqin Wang,

Takashi Sato,

Yutaka Uyeno,

Takeshi Shimosato

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/393598

Subject(s) - lactococcus lactis , dipeptidyl peptidase , hydrolysate , proteases , recombinant dna , biochemistry , chemistry , dipeptidyl peptidase 4 , trypsin , in vitro , proteolysis , enzyme , microbiology and biotechnology , biology , bacteria , lactic acid , hydrolysis , diabetes mellitus , type 2 diabetes , endocrinology , genetics , gene

Previous studies showed that hydrolysates of β -lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro . In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, suggesting that BLG-secreting L. lactis may be useful in the treatment of type 2 diabetes mellitus.

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