Synthesis and Antibacterial Screening of Some 1-Aroyl-3-aryl Thiourea Derivatives | Zendy

Love Kumar Soni | Zendy; Tamanrsinghani | Zendy; Rica Jain | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthesis and Antibacterial Screening of Some 1-Aroyl-3-aryl Thiourea Derivatives

Author(s) -

Love Kumar Soni,

Tamanrsinghani,

Rica Jain

Publication year - 2014

Publication title -

isrn medicinal chemistry

Language(s) - English

Resource type - Journals

ISSN - 2314-629X

DOI - 10.1155/2014/393102

Subject(s) - thiourea , antibacterial activity , bacteria , aryl , gram positive bacteria , chemistry , gram , gram negative bacteria , antibacterial agent , organic chemistry , escherichia coli , antibiotics , biochemistry , biology , antimicrobial , genetics , alkyl , gene

A series of 1-aroyl-3-aryl thioureas derivatives were synthesized and evaluated for antibacterial activity. The results indicated that the compounds possessed higher activity against gram-negative bacteria than gram-positive bacteria. Amongst all these compounds, C18 (89.4%) exhibited the greatest antibacterial activity against gram-negative bacteria while C5 (85.6%) displayed maximum antibacterial activity against gram-positive bacteria. Preliminary study of the structure-activity relationship revealed that an electronic factor on aryl rings had a great effect on the antibacterial activity of these compounds.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research