English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

The emergence of epidemic fungal pathogenic resistance to current antifungal drugs has increased the interest in developing alternative antibiotics from natural sources.  Cicer arietinum  is well known for its medicinal properties. The aim of this work was to isolate antimicrobial proteins from  Cicer arietinum . An antifungal protein, C-25, was isolated from  Cicer arietinum  and purified by gel filtration. C-25 protein was tested using agar diffusion method against human pathogenic fungi of ATCC strains and against clinical isolates of  Candida krusei ,  Candida tropicalis , and  Candida parapsilosis , and MIC values determined were varied from 1.56 to 12.5   μ  g/mL. The SEM study demonstrated that C-25 induces the bleb-like surface changes, irregular cell surface, and cell wall disruption of the fungi at different time intervals. Cytotoxic activity was studied on oral cancer cells and normal cells. It also inhibits the growth of fungal strains which are resistant to fluconazole. It reduced the cell proliferation of human oral carcinoma cells at the concentration of 37.5   μ  g/mL (IC 50 ) and no toxic effect was found on normal human peripheral blood mononuclear cells even at higher concentration of 600   μ  g/mL. It can be concluded that C-25 can be considered as an effective antimycotic as well as  antiproliferative  agent against human oral cancer cells.

Antifungal and Antiproliferative Protein fromCicer arietinum: A Bioactive Compound against Emerging Pathogens