Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats | Zendy

Agnieszka CudnochJędrzejewska | Zendy; Katarzyna Czarzasta | Zendy; Liana Puchalska | Zendy; Jakub Dobruch | Zendy; Olena Borowik | Zendy; Janusz Pachucki | Zendy; Ewa SzczepańskaSadowska | Zendy

Open Access

Angiotensin Converting Enzyme Inhibition Reduces Cardiovascular Responses to Acute Stress in Myocardially Infarcted and Chronically Stressed Rats

Author(s) -

Agnieszka CudnochJędrzejewska,

Katarzyna Czarzasta,

Liana Puchalska,

Jakub Dobruch,

Olena Borowik,

Janusz Pachucki,

Ewa SzczepańskaSadowska

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/385082

Subject(s) - captopril , medicine , blood pressure , angiotensin converting enzyme , myocardial infarction , heart rate , chronic stress , endocrinology , ace inhibitor , cardiology

Previous studies showed that chronically stressed and myocardially infarcted rats respond with exaggerated cardiovascular responses to acute stress. The present experiments were designed to elucidate whether this effect can be abolished by treatment with the angiotensin converting enzyme (ACE) inhibitor captopril. Sprague Dawley rats were subjected either to sham surgery (Groups 1 and 2) or to myocardial infarction (Groups 3 and 4). The rats of Groups 2 and 4 were also exposed to mild chronic stressing. Four weeks after the operation, mean arterial blood pressure (MABP) and heart rate (HR) were measured under resting conditions and after application of acute stress. The cardiovascular responses to the acute stress were determined again 24 h after administration of captopril orally. Captopril significantly reduced resting MABP in each group. Before administration of captopril, the maximum increases in MABP evoked by the acute stressor in all (infarcted and sham-operated) chronically stressed rats and also in the infarcted nonchronically stressed rats were significantly greater than in the sham-operated rats not exposed to chronic stressing. These differences were abolished by captopril. The results suggest that ACE may improve tolerance of acute stress in heart failure and during chronic stressing.

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