Open AccessComprehensive Analysis of MicroRNA and mRNA Expression in Normal and Tumorous Human Esophageal Squamous Cell Lines Using Microarray Datasets
Author(s) -
Ichiro Akagi,
Osamu Ishibashi,
Takeshi Matsutani,
Nobutoshi Hagiwara,
Akihisa Matsuda,
Tsutomu Nomura,
Hiroshi Makino,
Hiroshi Yoshida,
Masao Miyashita,
Eiji Uchida
Publication year - 2014
Publication title -
dataset papers in science
Language(s) - English
Resource type - Journals
ISSN - 2314-8497
DOI - 10.1155/2014/376541
Subject(s) - microrna , esophageal squamous cell carcinoma , microarray , microarray analysis techniques , biology , gene expression profiling , gene expression , gene , esophageal cancer , cell , cancer research , computational biology , cancer , bioinformatics , genetics
Despite the undisputed importance of altered microRNA (miRNA) expression in various cancers, there is limited information on the clinicopathologic significance of cancer-related miRNAs in esophageal squamous cell carcinoma (ESCC). Previously, it was reported that the expression of several miRNAs was dysregulated in ESCC. However, the target genes of these miRNAs have not been identified. Furthermore, additional miRNAs in humans have been discovered recently, indicating that revised miRNA and gene expression profiling for ESCC are necessary. Here, we provide datasets from microarray analyses to identify miRNA and mRNA expression comprehensively in Het-1A, a normal human esophageal squamous cell line, and three human ESCC cell lines
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