In SilicoIdentification and Characterization of Potential Drug Targets in Bovine Herpes Virus 4, Causing Bovine Mastitis

The purpose of this study is to deal with aetiology causing bovine mastitis; bovine herpes virusis also responsible for causing bovine mastitis but studies on viruses have been neglected ashistorical mastitis research has concentrated only on bacterial pathogens. Therefore, presentstudy aims to make an in silico identification and characterization of potential drug targets inbovine herpes virus 4 by computational methods using various bioinformatics tools. In thecurrent investigation 5 proteins of BoHV 4 were found to be nonhomologous to the host Bostaurus; these nonhomology proteins were believed to be inevitable proteins of BoHV 4 as theywere specific to the virus; however 378 proteins were homologous to the host protein. The in silicophysicochemical characterization of 5 proteins of BoHV 4 indicated that all the proteins of the viruswere having more or less similar characteristics. Perhaps the knowledge of the present study mayhelp in drug discovery which have high affinity to target site. Possible drug discovery to managebovine mastitis with a help of bioinformatics tool is more significant and, specific and, reduces time andcomplications involved in clinical trials