An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients | Zendy

Hirayuki Enomoto | Zendy; Nobuhiro Aizawa | Zendy; Hideji Nakamura | Zendy; Yoshiyuki Sakai | Zendy; Yoshinori Iwata | Zendy; Hironori Tanaka | Zendy; Naoto Ikeda | Zendy; Tomoko Aoki | Zendy; Yukihisa Yuri | Zendy; Kazunori Yoh | Zendy; Kenji Hashimoto | Zendy; Akio Ishii | Zendy; Tomoyuki Takashima | Zendy; Kazunari Iwata | Zendy; Masaki Saito | Zendy; Hiroyasu Imanishi | Zendy; Hiroko Iijima | Zendy; Shuhei Nishiguchi | Zendy

Open Access

An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients

Author(s) -

Hirayuki Enomoto,

Nobuhiro Aizawa,

Hideji Nakamura,

Yoshiyuki Sakai,

Yoshinori Iwata,

Hironori Tanaka,

Naoto Ikeda,

Tomoko Aoki,

Yukihisa Yuri,

Kazunori Yoh,

Kenji Hashimoto,

Akio Ishii,

Tomoyuki Takashima,

Kazunari Iwata,

Masaki Saito,

Hiroyasu Imanishi,

Hiroko Iijima,

Shuhei Nishiguchi

Publication year - 2014

Publication title -

gastroenterology research and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.622

H-Index - 45

eISSN - 1687-630X

pISSN - 1687-6121

DOI - 10.1155/2014/351396

Subject(s) - medicine , gastroenterology , albumin , liver fibrosis , prothrombin time , liver function , fibrosis , glycated hemoglobin , cholinesterase , hepatitis b virus , cirrhosis , liver function tests , platelet , diabetes mellitus , endocrinology , immunology , virus , type 2 diabetes

Background . In hepatitis B virus- (HBV-) positive patients, the relationship between the metabolic variables and histological degree of liver fibrosis has been poorly investigated. Methods . A total of 176 HBV-positive patients were assessed in whom the ratios of glycated albumin-to-glycated hemoglobin (GA/HbA1c) were calculated in order to investigate the relationship with the degree of liver fibrosis. Results . The GA/HbA1c ratio increased in association with the severity of fibrosis (METAVIR scores: F0-1: 2.61 ± 0.24, F2: 2.65 ± 0.24, F3: 2.74 ± 0.38, and F4: 2.91 ± 0.63). The GA/HbA1c ratios were inversely correlated with four variables of liver function: the prothrombin time (PT) percentage ( P < 0.0001), platelet count ( P < 0.0001), albumin value ( P < 0.0001), and cholinesterase value ( P < 0.0001). The GA/HbA1c ratio was positively correlated with two well-known markers of liver fibrosis, FIB-4 ( P < 0.0001) and the AST-to-platelet ratio index (APRI) ( P < 0.0001). Furthermore, the GA/HbA1c showed better correlations with two variables of liver function (PT percentage and cholinesterase value) than did FIB-4 and with all four variables than did the APRI. Conclusion . The GA/HbA1c ratio is associated with the degree of liver fibrosis in HBV-positive patients.

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