Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation | Zendy

Rona Banerjee | Zendy

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Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation

Author(s) -

Rona Banerjee

Publication year - 2014

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/2014/325873

Subject(s) - curcumin , chemistry , peptide , fibril , amyloid (mycology) , amyloid beta , inhibitory postsynaptic potential , biophysics , fourier transform infrared spectroscopy , atomic force microscopy , fibrillation , biochemistry , nanotechnology , chemical engineering , inorganic chemistry , medicine , materials science , engineering , biology , atrial fibrillation

Mononuclear complexes of Curcumin with Cu(II) and Zn(II) have been synthesized and, characterized and their effects on the fibrillization and aggregation of amyloid-beta (A β ) peptide have been studied. FTIR spectroscopy and atomic force microscopy (AFM) observations demonstrate that the complexes can inhibit the transition from less structured oligomers to β -sheet rich protofibrils which act as seeding factors for further fibrillization. The metal complexes also impart more improved inhibitory effects than Curcumin on peptide fibrillization.

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