ROS, Notch, and Wnt Signaling Pathways: Crosstalk between Three Major Regulators of Cardiovascular Biology | Zendy

Cristiana Caliceti | Zendy; Patrizia Nigro | Zendy; Paola Rizzo | Zendy; Roberto Ferrari | Zendy

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ROS, Notch, and Wnt Signaling Pathways: Crosstalk between Three Major Regulators of Cardiovascular Biology

Author(s) -

Cristiana Caliceti,

Patrizia Nigro,

Paola Rizzo,

Roberto Ferrari

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/318714

Subject(s) - wnt signaling pathway , notch signaling pathway , biology , crosstalk , microbiology and biotechnology , angiogenesis , signal transduction , progenitor cell , stem cell , neuroscience , cancer research , physics , optics

Reactive oxygen species (ROS), traditionally viewed as toxic by-products that cause damage to biomolecules, now are clearly recognized as key modulators in a variety of biological processes and pathological states. The development and regulation of the cardiovascular system require orchestrated activities; Notch and Wnt/ β -catenin signaling pathways are implicated in many aspects of them, including cardiomyocytes and smooth muscle cells survival, angiogenesis, progenitor cells recruitment and differentiation, arteriovenous specification, vascular cell migration, and cardiac remodelling. Several novel findings regarding the role of ROS in Notch and Wnt/ β -catenin modulation prompted us to review their emerging function in the cardiovascular system during embryogenesis and postnatally.

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