Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development | Zendy

ChiYun Wang | Zendy; ChiouFeng Lin | Zendy

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Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development

Author(s) -

ChiYun Wang,

ChiouFeng Lin

Publication year - 2014

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2014/308976

Subject(s) - annexin a2 , cancer , cancer research , cancer cell , biology , protease , annexin , immunology , flow cytometry , genetics , enzyme , biochemistry

Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management.

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