A Validated Method for the Quantitation of Ciprofloxacin Hydrochloride Using Diffuse Reflectance Infrared Fourier Transform Spectroscopy | Zendy

Bhoomendra A. Bhongade | Zendy; Sirajunisa Talath | Zendy; Sunil R. Dhaneshwar | Zendy

Open Access

A Validated Method for the Quantitation of Ciprofloxacin Hydrochloride Using Diffuse Reflectance Infrared Fourier Transform Spectroscopy

Author(s) -

Bhoomendra A. Bhongade,

Sirajunisa Talath,

Sunil R. Dhaneshwar

Publication year - 2014

Publication title -

international journal of spectroscopy

Language(s) - English

Resource type - Journals

eISSN - 1687-9457

pISSN - 1687-9449

DOI - 10.1155/2014/294612

Subject(s) - potassium bromide , ciprofloxacin hydrochloride , diffuse reflectance infrared fourier transform , fourier transform infrared spectroscopy , diffuse reflection , analytical chemistry (journal) , near infrared spectroscopy , correlation coefficient , potassium , fourier transform , infrared , spectroscopy , chemistry , materials science , chromatography , ciprofloxacin , mathematics , optics , statistics , mathematical analysis , biochemistry , physics , organic chemistry , photocatalysis , quantum mechanics , catalysis , antibiotics

A quantitative method using diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) was developed and validated for the estimation of ciprofloxacin in its tablet dosage forms. The solid-state samples were prepared by dilution in dry potassium bromide and were analyzed by FTIR spectrophotometer with DRIFT sampling technique. A linear relationship for the carbonyl peak area centered around 1709 cm−1 was observed in the range of 0.3–1.5% w/w with good correlation coefficient of 0.998. The percent recovery of ciprofloxacin in three marketed tablet dosage forms was in the range of 98.76 ± 0.27. The present reported method is precise, reproducible, and eco-friendly. DRIFTS may have a potential as an alternative method for qualitative and quantitative analysis of ciprofloxacin in bulk drugs and tablet dosage forms

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