Secondary Hemophagocytic Syndrome Associated with Richter’s Transformation in Chronic Lymphocytic Leukemia | Zendy

Nura ElHaj | Zendy; Wilson I. Gonsalves | Zendy; Vinay Gupta | Zendy; Jacob P. Smeltzer | Zendy; Sameer A. Parikh | Zendy; Preet Paul Singh | Zendy; Naseema Gangat | Zendy

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Secondary Hemophagocytic Syndrome Associated with Richter’s Transformation in Chronic Lymphocytic Leukemia

Author(s) -

Nura ElHaj,

Wilson I. Gonsalves,

Vinay Gupta,

Jacob P. Smeltzer,

Sameer A. Parikh,

Preet Paul Singh,

Naseema Gangat

Publication year - 2014

Publication title -

case reports in hematology

Language(s) - English

Resource type - Journals

eISSN - 2090-6560

pISSN - 2090-6579

DOI - 10.1155/2014/287479

Subject(s) - medicine , chronic lymphocytic leukemia , malignancy , lymphoma , immunology , inflammation , immune system , leukemia , pathology

Hemophagocytic syndrome (HPS) is an extremely rare condition arising from the overactivation of one's own immune system. It results in excessive inflammation and tissue destruction. Prompt initiation of treatment is warranted in either scenario in order to decrease mortality. Most cases are triggered by infectious agents, malignancy, or drugs. We describe the first case of a CLL patient presenting with HPS due to acquisition of EBV-related large cell lymphoma in the setting of profound immunodeficiency.

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