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Mycobacterium tuberculosis  (Mtb) is a pathogenic bacteria species in the genus  Mycobacterium  and the causative agent of most cases of tuberculosis. Tuberculosis (TB) is the leading cause of death in the world from a bacterial infectious disease. This antibiotic resistance strain lead to development of the new antibiotics or drug molecules which can kill or suppress the growth of  Mycobacterium tuberculosis . We have performed an  in silico  comparative analysis of metabolic pathways of the host  Homo sapiens  and the pathogen  Mycobacterium tuberculosis  (H37Rv). Novel efforts in developing drugs that target the intracellular metabolism of  M. tuberculosis  often focus on metabolic pathways that are specific to  M. tuberculosis . We have identified five unique pathways for  Mycobacterium tuberculosis  having a number of 60 enzymes, which are nonhomologous to  Homo sapiens  protein sequences, and among them there were 55 enzymes, which are nonhomologous to  Homo sapiens  protein sequences. These enzymes were also found to be essential for survival of the  Mycobacterium tuberculosis  according to the DEG database. Further, the functional analysis using Uniprot showed involvement of all the unique enzymes in the different cellular components.

Mycobacterium tuberculosis H37Rv: In Silico Drug Targets Identification by Metabolic Pathways Analysis