Chemokines as Potential Markers in Pediatric Renal Diseases | Zendy

Ana Cristina Simões e Silva | Zendy; André Pereira | Zendy; Mauro Martins Teixeira | Zendy; Antônio Lúcio Teixeira | Zendy

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Chemokines as Potential Markers in Pediatric Renal Diseases

Author(s) -

Ana Cristina Simões e Silva,

André Pereira,

Mauro Martins Teixeira,

Antônio Lúcio Teixeira

Publication year - 2014

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2014/278715

Subject(s) - chemokine , medicine , disease , intensive care medicine , kidney disease , pathophysiology , immunology , bioinformatics , pathology , inflammation , biology

Glomerular diseases and obstructive uropathies are the two most frequent causes of chronic kidney disease (CKD) in children. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric renal diseases. Among several putative biomarkers, chemokines emerge as promising molecules since they play relevant roles in the pathophysiology of pediatric renal diseases. The evaluation of these inflammatory mediators might help in the management of diverse renal diseases in children and the detection of patients at high risk to develop CKD. The aim of this paper is to revise general aspects of chemokines and the potential link between chemokines and the most common pediatric renal diseases by including experimental and clinical evidence.

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