Autophagy in HCV Infection: Keeping Fat and Inflammation at Bay | Zendy

Tiziana Vescovo | Zendy; Giulia Refolo | Zendy; Alessandra Romagnoli | Zendy; Fabiola Ciccosanti | Zendy; Marco Corazzari | Zendy; Tonino Alonzi | Zendy; Gian María Fimia | Zendy

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Autophagy in HCV Infection: Keeping Fat and Inflammation at Bay

Author(s) -

Tiziana Vescovo,

Giulia Refolo,

Alessandra Romagnoli,

Fabiola Ciccosanti,

Marco Corazzari,

Tonino Alonzi,

Gian María Fimia

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/265353

Subject(s) - autophagy , hepatitis c virus , inflammation , immunology , pathogenesis , immunity , biology , lipid metabolism , innate immune system , hepatitis c , hepacivirus , chronic infection , virus , virology , immune system , apoptosis , endocrinology , biochemistry

Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease. Viral persistence and pathogenesis rely mainly on the ability of HCV to deregulate specific host processes, including lipid metabolism and innate immunity. Recently, autophagy has emerged as a cellular pathway, playing a role in several aspects of HCV infection. This review summarizes current knowledge on the molecular mechanisms that link the HCV life cycle with autophagy machinery. In particular, we discuss the role of HCV/autophagy interaction in dysregulating inflammation and lipid homeostasis and its potential for translational applications in the treatment of HCV-infected patients.

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