Evidence for Association of the E23K Variant ofKCNJ11Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis | Zendy

Khaled Lasram | Zendy; Nizar Ben Halim | Zendy; Sana Hsouna | Zendy; Rym Kéfi | Zendy; Imen Arfa | Zendy; Welid Ghazouani | Zendy; H. Jamoussi | Zendy; Houda Benrahma | Zendy; Najla Kharrat | Zendy; Ahmed Rebaï | Zendy; Slim Ben Ammar | Zendy; Sonia Bahri | Zendy; Abdelhamid Barakat | Zendy; Abdelmajid Abid | Zendy; Sonia Abdelhak | Zendy

Open Access

Evidence for Association of the E23K Variant ofKCNJ11Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis

Author(s) -

Khaled Lasram,

Nizar Ben Halim,

Sana Hsouna,

Rym Kéfi,

Imen Arfa,

Welid Ghazouani,

H. Jamoussi,

Houda Benrahma,

Najla Kharrat,

Ahmed Rebaï,

Slim Ben Ammar,

Sonia Bahri,

Abdelhamid Barakat,

Abdelmajid Abid,

Sonia Abdelhak

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/265274

Subject(s) - type 2 diabetes , meta analysis , medicine , diabetes mellitus , allele , case control study , population , genetic association , genetics , oncology , genotype , gene , endocrinology , biology , single nucleotide polymorphism , environmental health

Aims . Genetic association studies have reported the E23K variant of KCNJ11 gene to be associated with Type 2 diabetes. In Arab populations, only four studies have investigated the role of this variant. We aimed to replicate and validate the association between the E23K variant and Type 2 diabetes in Tunisian and Arab populations. Methods . We have performed a case-control association study including 250 Tunisian patients with Type 2 diabetes and 267 controls. Allelic association has also been evaluated by 2 meta-analyses including all population-based studies among Tunisians and Arabs (2 and 5 populations, resp.). Results . A significant association between the E23K variant and Type 2 diabetes was found (OR = 1.6, 95% CI = 1.14–2.27, and P = 0.007). Furthermore, our meta-analysis has confirmed the significant role of the E23K variant in susceptibility of Type 2 diabetes in Tunisian and Arab populations (OR = 1.29, 95% CI = 1.15–1.46, and P < 10 −3 and OR = 1.33, 95% CI = 1.13–1.56, and P = 0.001, resp.). Conclusion . Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research