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In China  Atractylodis Rhizoma  is widely used for the treatment of rheumatic diseases and digestive disorders. Stir-frying with wheat bran is the most common processing method. In order to clarify the influence of processing on pharmacological properties of  Atractylodis Rhizoma , an investigation was carried out to compare the pharmacokinetics and tissue distribution of typical constituent after oral administration of raw  Atractylodis Rhizoma  and processed ones. A simple, rapid, and sensitive high performance liquid chromatography with UV detection was developed and validated for the determination of (4 E ,6 E ,12 E )-tetradecatriene-8,10-diyne-1,3-diyl diacetate in rat plasma. A chromatography was carried out on Diamonsil C 18  (250 × 4.6 mm; 5   μ  m) analytical column, using a mobile phase which consisted of acetonitrile and 0.1% phosphoric acid water (60 : 40, v/v) at a flow rate of 1.0 mL · min −1 . The wavelength was set at 336 nm. The LLOQ of (4 E ,6 E ,12 E )-tetradecatriene-8,10-diyne-1,3-diyl diacetate was 0.00143    μ   g · mL −1 . Both accuracy and precision were satisfactory. The pharmacokinetic results showed that the  T   max⁡  was 1 hour in advance and the  C   max⁡  was increased after processing. Tissue distribution showed that the highest level was in spleen. And the concentrations in the spleen were increased after stir-frying with bran.

journal of analytical methods in chemistry

Determination of (4E,6E,12E)-Tetradecatriene-8,10-diyne-1,3-diyl Diacetate in Rat Plasma and Tissues by HPLC-UV Method and Their Application to a Pharmacokinetic and Tissue Distribution Study