Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus) | Zendy

Rovena Clara Galvão Januário Engelberth | Zendy; Kayo Diogenes de A. Silva | Zendy; Carolina Virgínia Macêdo de Azevedo | Zendy; Elaine C. Gavioli | Zendy; José R. Santos | Zendy; Joacil Germano Soares | Zendy; Expedito Silva do Nascimento | Zendy; Judney Cley Cavalcante | Zendy; Miriam S.M.O. Costa | Zendy; Jeferson S. Cavalcante | Zendy

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Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus)

Author(s) -

Rovena Clara Galvão Januário Engelberth,

Kayo Diogenes de A. Silva,

Carolina Virgínia Macêdo de Azevedo,

Elaine C. Gavioli,

José R. Santos,

Joacil Germano Soares,

Expedito Silva do Nascimento,

Judney Cley Cavalcante,

Miriam S.M.O. Costa,

Jeferson S. Cavalcante

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/243825

Subject(s) - marmoset , suprachiasmatic nucleus , callithrix , nissl body , biology , neun , circadian rhythm , senescence , neurochemical , endocrinology , medicine , neuroscience , staining , microbiology and biotechnology , immunohistochemistry , immunology , paleontology , genetics

The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and nonhuman primates during aging. The effects of senescence on morphological aspects in SCN are important for understanding some alterations in biological rhythms expression. Therefore, our aim was to perform a comparative study of the morphological aspects of SCN in adult and aged female marmoset. Morphometric analysis of SCN was performed using Nissl staining, NeuN-IR, GFAP-IR, and CB-IR. A significant decrease in the SCN cells staining with Nissl, NeuN, and CB were observed in aged female marmosets compared to adults, while a significant increase in glial cells was found in aged marmosets, thus suggesting compensatory process due to neuronal loss evoked by aging.

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