Antiestrogenic and Anti-Inflammatory Potential of n-Hexane Fraction of Vitex negundo Linn Leaf Extract: A Probable Mechanism for Blastocyst Implantation Failure in Mus musculus | Zendy

Mehul Jivrajani | Zendy; Nirav M Ravat | Zendy; Sheetal Anandjiwala | Zendy; Manish Nivsarkar | Zendy

Open Access

Antiestrogenic and Anti-Inflammatory Potential of n-Hexane Fraction of Vitex negundo Linn Leaf Extract: A Probable Mechanism for Blastocyst Implantation Failure in Mus musculus

Author(s) -

Mehul Jivrajani,

Nirav M Ravat,

Sheetal Anandjiwala,

Manish Nivsarkar

Publication year - 2014

Publication title -

international scholarly research notices

Language(s) - English

Resource type - Journals

ISSN - 2356-7872

DOI - 10.1155/2014/241946

Subject(s) - superoxide dismutase , blastocyst , lipid peroxidation , andrology , chloroform , chemistry , hexane , traditional medicine , medicine , biochemistry , enzyme , chromatography , embryogenesis , gene

The anti-implantation potential of different fractions of Vitex negundo Linn leaf extract was evaluated in female Swiss Albino mice. Animals from different groups were dosed orally either with 0.2% agar (vehicle) or with fractions of V. negundo leaf extract ( n -hexane, chloroform, n -butanol, and remnant fractions) at 10:00 a.m., from day 1 to day 6 of pregnancy. The pregnant females from each group were sacrificed on different days of pregnancy ( n = 6), and uterus was excised and used for estimation of lipid peroxidation and assay of superoxide dismutase activity as a marker for blastocyst implantation. Animals treated with n -hexane fraction showed altered level of superoxide anion radical and superoxide dismutase activity as compared to control animals. The probable mechanism by which this extract exhibits inhibition of blastocyst implantation is through the anti-inflammatory and antiestrogenic potential.

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