Open AccessNatural Rubber Latex: Study of a Novel Carrier for Casearia sylvestris Swartz Delivery
Author(s) -
Felipe Azevedo Borges,
Luis Felipe Cesar Bolognesi,
Alberto Trecco,
Bruno de Camargo Drago,
Larisa B. Arruda,
Paulo Noronha LisboaFilho,
Elaíse Gonçalves Pierri,
Carlos F. O. Graeff,
André Gonzaga dos Santos,
Matheus Carlos Romeiro Miranda,
Rondinelli Donizetti Herculano
Publication year - 2014
Publication title -
isrn polymer science
Language(s) - English
Resource type - Journals
ISSN - 2090-8733
DOI - 10.1155/2014/241297
Subject(s) - natural rubber , drug delivery , chemistry , phenols , nuclear chemistry , materials science , organic chemistry
Natural rubber latex (NRL) from Hevea brasiliensis has showed interesting biomedical properties as improving wound healing, cell adherence, tissue formation, and angiogenesis. It is used for biosynthesis of nanoparticles, sensors and prosthesis and for drug delivery systems (for drugs, plant extracts, and nanoparticles). To enhance its wound healing properties was incorporated Casearia sylvestris Swartz extract, whose pharmacological activity includes anti-inflammatory, analgesic, antiseptic, antiulcer, and antitumor due to its casearins and phenols. Results showed the prolonged release of its compounds (35 days) and the mechanism of release is super case II ( > 1) by Korsmeyer-Peppas model. Although SEM shows different sizes of clusters at the surface, the release is homogeneous through the biomembrane. FTIR shows no interaction between the matrix and the extract, with computation of the presence of some casearins
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