Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance | Zendy

Jing Su | Zendy; Lei Zhou | Zendy; Meihui Xia | Zendy; Ye Xu | Zendy; Xiyan Xiang | Zendy; Liankun Sun | Zendy

Open Access

Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance

Author(s) -

Jing Su,

Lei Zhou,

Meihui Xia,

Ye Xu,

Xiyan Xiang,

Liankun Sun

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/234370

Subject(s) - crosstalk , endoplasmic reticulum , mitochondrion , microbiology and biotechnology , apoptosis , unfolded protein response , bcl 2 family , programmed cell death , organelle , biology , signal transduction , cancer research , genetics , physics , optics

Tumor cells overexpress antiapoptotic proteins of the Bcl-2 (B-cell leukemia/lymphoma-2) family, which can lead to both escape from cell death and resistance to chemotherapeutic drugs. Recent studies suggest that the endoplasmic reticulum (ER) can produce proapoptotic signals, amplifying the apoptotic signaling cascade. The crosstalk between mitochondria and ER plays a decisive role in many cellular events but especially in cell death. Bcl-2 family proteins located in the ER and mitochondria can influence not only the function of the two organelles but also the interaction between them. Therefore, the Bcl-2 family of proteins may also be involved in the mechanism of tumor chemotherapy resistance by influencing crosstalk between the ER and mitochondria. In this review we will briefly discuss evidence to support this concept.

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