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The present study describes the beneficial effects of potential probiotic  E. coli  16 (pUC8:16 gfp ) expressing  Vitreoscilla  hemoglobin ( vgb ) gene, associated with bacterial respiration under microaerobic condition, on gastrointestinal (GI) colonization and its antioxidant activity on carbon tetrachloride (CCl 4 ) induced toxicity in Charles Foster rats.  In vitro , catalase activity in  E. coli  16 (pUC8:16 gfp ) was 1.8 times higher compared to  E. coli  16 (pUC- gfp ) control.  In vivo ,  E. coli  16 (pUC8:16 gfp ) not only was recovered in the fecal matter after 70 days of oral administration but also retained antibacterial activities, whereas  E. coli  16 (pUC- gfp ) was not detected. Oral administration of 200 and 500  μ L/kg body weight of CCl 4  to rats at weekly interval resulted in elevated serum glutamyl pyruvate transaminase (SGPT) and serum glutamyl oxalacetate transaminase (SGOT) levels compared to controls. Rats prefed with  E. coli  16 (pUC8:16 gfp ) demonstrated near to normal levels for SGPT and SGOT, whereas the liver homogenate catalase activity was significantly increased compared to CCl 4  treated rats. Thus, pUC8:16 gfp  plasmid encoding  vgb  improved the growth and GI tract colonization of  E. coli  16. In addition, it also enhanced catalase activity in rats harboring  E. coli  16 (pUC8:16 gfp ), thereby preventing the absorption of CCl 4  to GI tract.

biomed research international

Potential Probiotic<i>Escherichia coli</i>16 Harboring the<i>Vitreoscilla</i>Hemoglobin Gene Improves Gastrointestinal Tract Colonization and Ameliorates Carbon Tetrachloride Induced Hepatotoxicity in Rats

Potential ProbioticEscherichia coli16 Harboring theVitreoscillaHemoglobin Gene Improves Gastrointestinal Tract Colonization and Ameliorates Carbon Tetrachloride Induced Hepatotoxicity in Rats