Nitric Oxide, Oxidative Stress, andp66ShcInterplay in Diabetic Endothelial Dysfunction | Zendy

Alessandra Magenta | Zendy; Simona Greco | Zendy; Maurizio C. Capogrossi | Zendy; Carlo Gaetano | Zendy; Fabio Martelli | Zendy

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Nitric Oxide, Oxidative Stress, andp66ShcInterplay in Diabetic Endothelial Dysfunction

Author(s) -

Alessandra Magenta,

Simona Greco,

Maurizio C. Capogrossi,

Carlo Gaetano,

Fabio Martelli

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/193095

Subject(s) - oxidative stress , computer science , chemistry , biochemistry

Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review, we summarized the molecular mechanisms underpinning diabetic endothelial and vascular dysfunction. In particular, we focused our attention on the complex interplay existing among NO, reactive oxygen species (ROS), and one crucial regulator of intracellular ROS production, p66 Shc protein.

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